Abstract
The familial incidence of primary nocturnal enuresis is well recognised. Twin studies suggest there to be a significant genetic component to the aetiology of this disorder. However, family studies to date have been based on symptomatic enquiry alone although detrusor instability is a recognised feature of primary noctural enuresis in 70–80% of cases. For the first time we describe a family of adults with urodynamically proven instability spanning three generations. The pattern of inheritance lends support to the proposition that such detrusor instability is transmitted as an autosomal dominant characteristic.