Dicentric Y Chromosome Without Evidence of Mosaicism in an Azoospermic Male

Isoji Sasagawa Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan

Manabu Ishigooka Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan

Tomoyuki Kato Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan

Shinsuke Hayami Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan

Tohru Hashimoto Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan

Teruhiro Nakada Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan

Abstract

A phenotypically male of dicentric Y chromosome with no evidence of sex chromosomal mosaicism is reported. Staining of fluorescence in situ hybridization using Y chromosome centromere-specific DNA probe showed the presence of two bright fluorescent spots in Y chromosome. Testicular histology revealed maturation arrest at the stage of primary spermatocyte. It is suggested that structural anomaly of the Y chromosome is related to the disturbance of spermatogenesis.

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Dicentric Y Chromosome Without Evidence of Mosaicism in an Azoospermic Male

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Dicentric Y Chromosome Without Evidence of Mosaicism in an Azoospermic Male

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