Short-arm Dicentric Y Chromosome Associated with Sertoli-cell-only Tubule

Yuichi Adachi Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

Isoji Sasagawa Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

Masahiko Tomaru Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

Manabu Ishigooka Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

Yoko Kubota Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

Teruhiro Nakada Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

Abstract

We report a case of a short-arm dicentric Y chromosome associated with Sertoli-cell-only tubule. Chromosomal analysis, using G- and C-banding techniques, revealed: 45,X/46,X psu dic(Y) (pter→q11 ::q11→pter)/46,X+mar. Staining by fluorescence in situ hybridization using a Y chromosome centromere-specific DNA probe showed two bright spots in the pseudodicentric Y chromosome and one in the marker chromosome. It is assumed that Sertoli-cell-only tubule is caused by deletion or disruption of the azoospermic factor gene located distal in Yq11.

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Short-arm Dicentric Y Chromosome Associated with Sertoli-cell-only Tubule

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Short-arm Dicentric Y Chromosome Associated with Sertoli-cell-only Tubule

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