Allergic Nephropathy Associated with Norfloxacin and Ciprofloxacin Therapy: Report of Two Cases and Review of the Literature

Abstract

Allergic nephropathy associated with quinolone antibiotics has been reported in an increasing number of cases. The mechanism might be a hypersensitivity reaction. Norfloxacin has been incriminated previously as a cause once only, with acute interstitial nephritis (AIN) as the histopathological finding. Ciprofloxacin-associated nephropathy has been reported in 28 cases, with AIN as the main histopathological finding. This report describes a second case of AIN associated with norfloxacin treatment and another ciprofloxacin-associated renal interstitial drug adverse reaction. Clinicians should be aware of quinolone-associated AIN, which is a rare but potentially dangerous renal complication.

Key Words:

• acute interstitial nephritis
• acute renal failure
• ciprofloxacin
• norfloxacin
• omeprazole
• renal biopsy