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Scandinavian Journal of Urology and Nephrology Volume 31, 1997 - Issue 5
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Original Article

Interstitial Cystitis and Bladder Mastocytosis in a Woman with Chronic Urticaria

Grannum R. Sant Department of Urology, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA
,
Theoharis C. Theoharides Department of Pharmacology, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA
,
Richard Letourneau Department of Pharmacology, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA
&
Jeffrey Gelfand Department of Medicine, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA
Pages 497-500 | Received 08 Nov 1996, Accepted 10 Dec 1996, Published online: 09 Jul 2009
 
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Abstract

A patient with chronic urticaria and angioedema developed endoscopically confirmed interstitial cystitis. Bladder biopsy revealed bladder mastocytosis with >60 mast cells/mm2 (normal <10) in the detrusor and submucosa. Most of the mast cells were activated and degranulated. The occurrence of IC in a patient with urticaria and angioedema, diseases both associated with mast cell pathophysiology, supports the role of mast cells in interstitial cystitis.

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