9
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Expression of Glutathione S-Transferase Activity and Glutathione Content in Squamous Cell Carcinoma of Bladder Associated with Schistosomiasis in a Population in Egypt

, , , , &
Pages 43-47 | Received 01 Dec 1995, Accepted 20 Mar 1996, Published online: 09 Jul 2009
 

Abstract

The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with schistosomiasis cystitis tissue (n = 42) (4-fold, p = 1 × 10-12) and with healthy control samples (n = 9) (10-fold, p = 1 × 10-6). The glutathione content was also significantly higher in bladder cancer than in cystitis tissue (2-fold, p = 8 × 10-6) and in control samples (6-fold, 8 × 10-6). When control mucosa and cystitis samples were compared, 2-fold increased values were obtained for glutathione-S transferase (p = 4 × 10-3) and glutathione (p = 1 × 10-3) in schistosomiasis bladder tissue. Results describe an over-expression of glutathione-S transferase and glutathione levels in squamous cell carcinoma of the bladder, and indicate a possible role in chemoresistance to pharmacological therapy.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.