Abstract
Telithromycin and metformin have been reported to be commonly metabolized via hepatic CYP3A1/2 in rats. Community-acquired respiratory tract infection was reported to be frequent in patients with diabetes mellitus. Compared with controls, hepatic CYP3A1/2 was reported to be increased in male rats with diabetes mellitus induced by streptozotocin (DMIS rats).
After the intravenous administration of both drugs together to male DMIS rats, the time-averaged non-renal clearance (CLNR) of metformin was significantly slower (by 33.1%; 10.3 versus 15.4 ml min−1 kg−1) than metformin alone due to the inhibition of hepatic metabolism of metformin by telithromycin via CYP3A1/2.
After the oral administration of both drugs together, the total area under the plasma concentration–time curve (AUC) of metformin was comparable possibly due to the increased intestinal metabolism of metformin by telithromycin.
Acknowledgements
The authors thank the Sanofi-Aventis Group for the supply of telithromycin. This study was supported in part by 2008 BK21 Project for Applied Pharmaceutical Life Sciences.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.