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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 10
259
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Topics in Xenobiochemistry

Racemates revisited: heterochiral assemblies and the example of dl-thalidomide

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Pages 837-843 | Received 04 Apr 2011, Accepted 19 May 2011, Published online: 05 Jul 2011
 

Abstract

The existence of racemic compounds, comprised of pairs of opposite enantiomers as discrete molecular entities, has been accepted for over a century. However, their ability to remain as associated dimers when in solution is uncertain, if not generally doubted. In this article, data has been assembled to provide evidence for the presence of intact dimeric heterochiral assemblies in solution and presents DL-thalidomide as a probable example of this phenomenon.

Acknowledgement

The authors are grateful to Prof. John Lindon and Prof. Jeremy Nicholson for their constructive review of the manuscript and their comments.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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