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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 1
165
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Commentary

Drug peptide conjugates in human urine?

, &
Pages 89-93 | Received 25 Apr 2013, Accepted 15 May 2013, Published online: 18 Jun 2013
 

Abstract

1. Once in a while, during drug metabolism studies, an unusual or unexpected pathway is unearthed.

2. Such quirky finds open a refreshing hiatus, providing a departure from the, perhaps now mundane, textbook routes.

3. This brief missive draws attention to an interesting anecdote that may be unknown to some and concerns a substituted thioxanthenone drug.

Acknowledgements

The authors would like to thank Mr J. O’Gorman for assistance with the synthesis of lucanthone hydrochloride and Dr J. E. Fox of Alta Bioscience for analyses of the urine samples.

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