The impact of the concentration of drug binding plasma proteins on drug distribution according to Øie-Tozer’s model

Abstract

1. New equations have been developed from an updated version of Øie-Tozer’s model expressing how the free concentration and volume of distribution change in relation to changes in the concentration of drug binding plasma proteins. This updated model accommodates more than one drug binding plasma protein to contribute to the plasma protein binding.

2. Demonstrations of the model show that variability in the concentration of one plasma protein has considerably less impact on the free drug concentration and volume of distribution if other plasma proteins contribute to binding, than if they don’t.

• Disposition
• dose fraction
• free fraction
• orosomucoid
• serum albumin

Declaration of interest

The author reports no declarations of interest.