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Abstract
1. Evidence is presented to show that in primary, secondary and tertiary aralkylamines, N-oxidation and α-C-oxidation involve separate metabolic routes; steric and stereochemical features, enzyme inhibition, induction, development and alteration are used in the studies.
2. Metabolic oxidation of tertiary nitrogen atoms gives N-oxides, while oxidation of secondary and primary aliphatic amines gives hydroxylamines.
3. The chemical breakdown of hydroxylamines to oximes, ketones and aldehydes under different conditions is discussed.
4. The importance of distinguishing between metabolites and their chemical breakdown products, ‘metabonates’, is stressed.