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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 2
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Research Article

The Metabolism of S-2-Cyanoethyl-N-[(Methylcarbamoyl)Oxy]Thioacetimidate, an Insecticidal Carbamate, in the Rat

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Pages 179-191 | Received 01 Jun 1971, Published online: 15 Sep 2008
 

Abstract

1. The insecticidally active carbamate, S-2-cyanoethyl-N-[(methylcarbamoyl)oxy]thio[1,2-14C]acetimidate (Shell compound WL 21959) is rapidly metabolized and excreted when ingested orally by rats. Metabolites are excreted mainly in the urine (40% of the dose) and exhaled air (36% of the dose). Less than 5% of the administered radioactivity is retained in the animals after 4 days.

2. Metabolites found in the urine are: I, unchanged compound; II, the hydroxythioacetimidate derived from I; III, the O-sulphate of II; and IV, the O-glucuronide of II.

3. Metabolites in the respired air are carbon dioxide and acetonitrile.

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