Abstract
1. The ability of rats to degrade [14C]Ionox 330 in the alimentary canal was not altered by prior feeding of the compound.
2. [14C]Ionox 330 was not absorbed from the alimentary canal of pretreated animals.
3. A small quantity of Ionox 330 was oxidized within the alimentary canal followed by a limited absorption of the products.
4. The oxidation of Ionox 330 within the gut and the absorption of products were independent of dose level (20 and 400 mg/kg body weight).
5. It is unlikely that an enzymic mechanism is involved in the initial stage of oxidation of Ionox 330 in vivo