Dealkylation and N-Oxidation in the Metabolism of I-Diethylcarbamyl-4-Methylpiperazine in the Rat

Abstract

1. When [¹⁴C]1-diethylcarbamyl-4-methylpiperazine was orally administered to rats, 97% of the radioactivity was excreted in the 24 h urine. Unchanged drug excreted in the urine accounted for about 15% of the dose.

2. Two major metabolites present in the urine have been identified as 1-ethylcarbamyl-4-methylpiperazine (about 23% dose) and as 1-diethylcarbamyl-4-methylpiperazine-4-oxide (about 50% dose).