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Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 1
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Research Article

Dealkylation and N-Oxidation in the Metabolism of I-Diethylcarbamyl-4-Methylpiperazine in the Rat

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Pages 59-68 | Received 12 Oct 1971, Published online: 22 Sep 2008
 

Abstract

1. When [14C]1-diethylcarbamyl-4-methylpiperazine was orally administered to rats, 97% of the radioactivity was excreted in the 24 h urine. Unchanged drug excreted in the urine accounted for about 15% of the dose.

2. Two major metabolites present in the urine have been identified as 1-ethylcarbamyl-4-methylpiperazine (about 23% dose) and as 1-diethylcarbamyl-4-methylpiperazine-4-oxide (about 50% dose).

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