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Abstract
1. The absorption, excretion and biotransformation of 14C-labelled 2-[(methylsulphinyl)acetyl] pyridine (oxisuran) was studied in the dog.
2. The compound was absorbed readily, established high blood levels of radioactivity and was excreted predominantly in the urine.
3. Three urinary drug metabolites were identified and their structures established that oxisuran was subjected to both reductive and oxidative conversions.
4. The major metabolic pathway involved reduction of the carbonyl group followed by oxidation of the sulphoxide group : oxisuran α-(methylsulphinyl)-methyl-2-pyridinemethanol α-(methylsulphonyl)methyl-2-pyridine-methanol.
5. Oxidation preceded reduction in the minor metabolic sequence and yielded the same end product via 2-(methylsulphonyl)acetyl pyridine.