Oxidative Drug Metabolism in the Perinatal Rabbit Liver and Placenta: A Biochemical and Morphologic Study

Anders Rane Department of Pharmacology (Division of Clinical Pharmacology), Karolinska Institutet, Stockholm, Sweden; Department of Forensic Medicine, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Pathology, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden

Margareta Berggren Department of Pharmacology (Division of Clinical Pharmacology), Karolinska Institutet, Stockholm, Sweden; Department of Forensic Medicine, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Pathology, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden

Sumner Yaffe Department of Pharmacology (Division of Clinical Pharmacology), Karolinska Institutet, Stockholm, Sweden; Department of Forensic Medicine, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Pathology, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, State University of New York, Buffalo, New York, USA

Jan L. E. Ericsson Department of Pharmacology (Division of Clinical Pharmacology), Karolinska Institutet, Stockholm, Sweden; Department of Forensic Medicine, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Pathology, Sabbatsberg's Hospital, Karolinska Institutet, Stockholm, Sweden

Abstract

1. Development of the endoplasmic reticulum and its drug-oxidizing enzyme system was studied in perinatal rabbit liver and placenta from the 20th day of gestation to the 14th day of life.

2. The components of the microsomal drug-oxidizing electron transport chain and the drug-oxidizing capacity are absent, or present at negligible levels, in prenatal rabbit liver. A marked increase of the activities takes place at birth and during the first 2 weeks of life. Adult levels are not attained by the 14th day of life.

3. Rough surfaced endoplasmic reticulum in the form of cisternae was observed on the 20th day of gestation in the foetal rabbit liver. Prenatally, the endoplasmic reticulum was mainly rough surfaced, whereas the smooth surfaced reticulum appeared after birth.

4. Our findings show species difference in the development of the drug-oxidizing enzyme system between man and animals investigated, since human foetal liver contains the drug-oxidizing enzyme system.

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Oxidative Drug Metabolism in the Perinatal Rabbit Liver and Placenta: A Biochemical and Morphologic Study

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Oxidative Drug Metabolism in the Perinatal Rabbit Liver and Placenta: A Biochemical and Morphologic Study

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