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Abstract
1. Vitavax (carboxin) administered orally to rats and rabbits leads to the excretion of unchanged Vitavax both in the urine and faeces.
2. The major metabolites excreted in the urine were found to be glucuronides of phenols formed by hydroxylation of the parent compound. Vitavax sulphoxide did not appear to be a metabolite.
3. Administration of 14C-labelled Vitavax showed radioactivity in the salivary gland, liver, kidney and gastrointestinal tract; the compound did not undergo significant ring scission in vivo.