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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 2
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Research Article

The Metabolism of Salbutamol in Man

Marion E. Evans Asthma Research Council Clinical Pharmacology Unit, Department of Medicine, Cardiothoracic Institute, Brompton Hospital, London, SW3, UK
,
S. R. Walker Asthma Research Council Clinical Pharmacology Unit, Department of Medicine, Cardiothoracic Institute, Brompton Hospital, London, SW3, UK
,
R. T. Brittain Asthma Research Council Clinical Pharmacology Unit, Department of Medicine, Cardiothoracic Institute, Brompton Hospital, London, SW3, UK; Department of Pharmacology, Research Division, Allen & Hanburys Ltd, Ware, Herts, UK
&
J. W. Paterson Asthma Research Council Clinical Pharmacology Unit, Department of Medicine, Cardiothoracic Institute, Brompton Hospital, London, SW3, UK
Pages 113-120 | Received 10 Oct 1972, Published online: 14 Oct 2008
 
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Abstract

1. The fate of 3H-salbutamol given orally, by aerosol and intravenously, has been investigated in asthmatic patients.

2. Salbutamol was extensively metabolized to a polar metabolite. Both free salbutamol and the metabolite were excreted in the urine, the ratio varying with the route of administration.

3. The metabolite found in man is different from that previously found in the rat and the rabbit. Details of its chemical properties are given.

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