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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 6
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Research Article

The Absorption of Nicotine-1′-N-Oxide and its Reduction in the Gastro-Intestinal Tract in Man

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Pages 341-349 | Received 22 Sep 1972, Published online: 14 Oct 2008
 

Abstract

1. Nicotine-1′-N-oxide is reduced to nicotine in the lower gastro-intestinal tract in man after oral administration.

2. No reduction or metabolism in vivo occurred by other routes after administration of the N-oxide by intravenous injection.

3. Rapid absorption of nicotine and nicotine-1′-N-oxide occurred from the upper gastro-intestinal tract but absorption of N-oxide was incomplete.

4. The hepatic first-pass phenomenon shown by nicotine was dependent upon the site of absorption in the gastro-intestinal tract.

5. No apparent lipid solubility of nicotine-1′-N-oxide could be demonstrated by the buccal absorption test.

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