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Abstract
1. The metabolism of Benomyl (methyl 1-(butylcarbamoyl)-benzimidazol-2-ylcarbamate) has been studied in mice, rabbits and sheep, and in enzyme preparations from these species.
2. In all three species two metabolites were formed by hydroxylation, and two by ester hydrolysis. The hydroxylated metabolites were excreted from all species as the sulphate and glucuronide conjugates. Conjugates with acetic acid were not detected.
3. About 20% of the dose administered to each species was eliminated as conjugates of hydroxylated metabolites. Formation of hydroxylated metabolites was inhibited by SKF 525A in vitro.
4. In liver enzyme preparations from all three species, 2-amino-benzimidazole was hydroxylated to give 5-hydroxy-2-aminobenzimidazole.
