Abstract
1. Sample preparation procedures, derivative formation, conditions for separation, qualitative identification and quantitative evaluation of foreign compounds and their metabolites by g.l.c. are described and discussed.
2. The selective nitrogen flame ionization detector and the linear electron capture detector are proposed for use in the detection of the low therapeutic concentrations of drugs and drug metabolites in biological samples. The advantages in using selective detectors are : simplified sample extraction procedure, high detection sensitivity even for small sample volumes, sensitivity independent from sample matrix, speed of analysis.