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Abstract
1. Acenaphthen-1-ol is dehydrogenated to acenaphthen-1-one in the rat and in subcellular fractions of rat liver fortified with oxidized nicotinamide nucleotides.
2. 1,8-Naphthalic acid has been isolated as its anhydride from the urine of rats dosed with either acenaphthen-1-ol or acenaphthen-1-one.
3. Acenaphthen-1-one is oxidized to acenaphthene-1,2-quinone on incubation with a rat liver microsomal fraction fortified with an NADPH-generating system.
4. Although 1,8-naphthalic acid is the major metabolite excreted by rats dosed with acenaphthen-1-ol or acenaphthen-1-one only trace amounts of the acid are detected in incubation systems containing the alcohol or ketone.