Uptake of ω-Amino Acids by Rat Small Intestine and Kidney Cortex in vitro

Abstract

1. The mode of uptake of some ω-amino acids was studied in vitro using everted sacs prepared from rat small intestine.

2. The therapeutic, antifibrinolytic compounds, ϵ-aminocaproic acid (Epsicapron) and trans-4-aminomethylcyclohexanecarboxylic acid (Cyclocapron) were not actively transported against the concentration gradient.

3. β-Alanine, DL-β-aminoisobutyric acid, γ-aminobutyric acid, δ-aminovaleric acid and ω-aminocaprylic acid failed to show active transport with small intestine in vitro.

4. DL-β-Aminoisobutyric acid, Epsicapron, Cyclocapron and ω-amino-caprylic acid transferred from the intestine by diffusion down the concentration gradient.

5. Epsicapron, Cyclocapron and β-alanine were accumulated to a small extent by kidney-cortex slices.