Identification of New Water-Soluble Metabolites of Acetanilide

Preston H. Grantham National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, U.S.A.

Letitia C. Mohan National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, U.S.A.

Elizabeth K. Weisburger National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, U.S.A.

Henry M. Fales National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, U.S.A.

Edward A. Sokoloski National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, U.S.A.

John H. Weisburger National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, U.S.A.

Abstract

Two new urinary metabolites of acetanilide in rats were shown to be the mer-capturic acid derivatives3-[(5-acetamido-2-hydroxyphenyl)thio]-N-acetylalanine and 3-[5-acetamidophenyl)thio]-N-acetylalanine. They accounted for 7–10 and 1–3% of urinary radioactivity, respectively. Their mode of formation may involve an intermediate expoxide.

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Identification of New Water-Soluble Metabolites of Acetanilide

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Identification of New Water-Soluble Metabolites of Acetanilide

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