Absorption of Disodium Cromoglycate from the Rat Lung: Evidence of Carrier Transport

Abstract

1. Pulmonary absorption studies in the rat with 0–01–100 mM solutions of disodium cromoglycate (DSCG) indicated that absorption occurred in part by a saturable, carrier-type transport process and in part by diffusion.

2. Carrier transport became saturated at DSCG concentrations greater than 50 mM, and the transport maximum was estimated to be 92 μg/h under the conditions of these experiments.

3. Transport was inhibited by certain other organic anions including phenol red, chlorphenol red, benzylpenicillin and cephalothin. Moreover, DSCG inhibited the carrier transport of phenol red.

4. The results suggested that DSCG and phenol red share a common transport process for their absorption from the lung.