Abstract
1. The chemical instability of prazitone was reflected in urinary metabolites excreted by the rabbit. The compound rearranges in vivo to a mixture of isomeric 2-allophanoyl-2-phenyl-3-oxo-octahydroindolizidines, which were then hydroxylated in the indolizidinone ring.
2. The hydroxylated metabolites excreted in urine accounted for 45.5% of an oral dose, with <1% excreted as non-hydroxylated compounds.