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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 11
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Research Article

Excretion of Metabolites of Prazitone Hydrochloride (D, L-5-phenyl-5-(2-piperidinylmethyl)barbituric acid hydrochloride) in Rabbit Urine

Pages 665-668 | Received 08 Jan 1974, Published online: 22 Sep 2008
 

Abstract

1. The chemical instability of prazitone was reflected in urinary metabolites excreted by the rabbit. The compound rearranges in vivo to a mixture of isomeric 2-allophanoyl-2-phenyl-3-oxo-octahydroindolizidines, which were then hydroxylated in the indolizidinone ring.

2. The hydroxylated metabolites excreted in urine accounted for 45.5% of an oral dose, with <1% excreted as non-hydroxylated compounds.

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