The Identification of Three New Metabolic Products of Phentermine after Liver Microsomal Incubation

Abstract

1. N-Hydroxyphentermine (II), α, α-dimethyl-α-nitroso-β-phenylethane (III) and α, α-dimethyl-α-nitro-β-phenylethane (IV) were obtained from ethereal or n-pentane extracts after incubation of phentermine (I) with 10 000 g and 140 000 g liver microsomal preparations of various animal species.

2. The metabolites (II and III) produced the metabonate (IV) under aqueous alkaline conditions.

3. The structure, synthesis and physico-chemical and metabolic characteristics of these compounds are reported.