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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 5
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Research Article

Nephrotoxicity and Molecular Structure

I. C. Calder Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
P. J. Williams Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
R. A. Woods Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
C. C. Funder Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
C. R. Green Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
K. N. Ham Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
&
J. D. Tange Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
 show all
Pages 303-307 | Received 17 Feb 1974, Accepted 10 Jan 1975, Published online: 22 Sep 2008
 
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Abstract

The nephrotoxicity of a number of aminophenols, quinols and catechols has been assessed from the extent of necrosis of proximal convoluted tubules produced by intravenous injection in rats, and the toxicity correlated with the oxidation-reduction potentials of the compounds.

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