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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 4
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Research Article

Enzymic Reduction of Aromatic Hydrocarbon Epoxides by the Microsomal Fraction of Rat Liver

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Pages 197-203 | Received 11 Sep 1974, Published online: 22 Sep 2008
 

Abstract

1. The oxidation of aromatic hydrocarbons to arene oxides and the reduction of these oxides to the parent hydrocarbons are both catalysed by enzymes in the microsomal fraction of rat liver. A suggested name for the enzyme concerned in the reduction of these epoxides is 'epoxide reductase'.

2. 'Epoxide reductase' is NADPH-dependent and is inhibited by oxygen.

3. Preliminary investigations suggest that the enzyme is specific for both 'K-region' and 'non-K-region' arene oxides.

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