Metabolism of Sulphadiazine in Goats

Abstract

1. Following intravenous administration of sulphadiazine (2-sulphanilamido-pyrimidine) to goats, unchanged sulphadiazine comprised the major part of the total sulphonamide in blood plasma, milk and urine samples.

2. Relatively small amounts of N⁴-acetylsulphadiazine were excreted in milk and urine. The amount of conjugated metabolites in urine was small, but was comparatively large in the milk samples.

3. A new metabolite, 2-sulphanilamido-4-hydroxypyrirnidine, which comprised about 15% of the total sulphonamide in urine was isolated.