![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
1. Following intravenous administration of sulphadiazine (2-sulphanilamido-pyrimidine) to goats, unchanged sulphadiazine comprised the major part of the total sulphonamide in blood plasma, milk and urine samples.
2. Relatively small amounts of N4-acetylsulphadiazine were excreted in milk and urine. The amount of conjugated metabolites in urine was small, but was comparatively large in the milk samples.
3. A new metabolite, 2-sulphanilamido-4-hydroxypyrirnidine, which comprised about 15% of the total sulphonamide in urine was isolated.