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Abstract
1. After hydrolysis with glusulase of bile from rats treated with papaverine, four metabolites (A, B, C and D) were separated.
2. The structures of A, B and C were established as the monodemethylated compounds, 4′-desmethyl-, 7-desmethyl-, and 6-desmethylpapaverine, respectively.
3. D was formed from papaverine by bis-demethylation. Since it was found in cat bile after administering either A or C, but not B, it was identified as 4′,6-desmethylpapaverine.