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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 7
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Research Article

The Metabolism of Chlorpromazine and Promethazine to give new ‘Pink Spots’ Proposals for the Mechanisms Involved

A. H. Beckett Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3
Pages 449-452 | Received 29 May 1975, Published online: 22 Sep 2008
 
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Abstract

Mechanisms are proposed for the removal, during metabolism, of the aminoalkyl side chain from chlorpromazine and promethazine and for the subsequent formation of nitroxides, N-hydroperoxides, N-oxyhydroperoxides and hydroxylamines from the phenothiazine nuclei.

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