Levels of Piribedil and its Active Metabolite (S-584) in the Rat Striatum: Xenobiotica: Vol 5, No 10

Xenobiotica

the fate of foreign compounds in biological systems

Volume 5, 1975 - Issue 10

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Abstract

1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue.

2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

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Levels of Piribedil and its Active Metabolite (S-584) in the Rat Striatum

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Levels of Piribedil and its Active Metabolite (S-584) in the Rat Striatum

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