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Abstract
1. The properties of the rabbit liver microsomal enzyme system(s) catalysing the formation of N,N-dibenzylhydroxylamine as the major metabolite of dibenzylamine have been investigated.
2. The system consists of NADPH- and NADH-dependent components which are differentiated by their different pH optima and sensitivity towards cyanide.
3. The effect of various metabolic inhibitors on the N-oxidation process in vitro are investigated.
4. The N-oxidation of the parent amine was inhibited by CO, SKF 525-A, and inhibitors known to interact with microsomal cytochrome P-450. Phenobarbitone pre-treatment stimulates further metabolism of the hydroxylamine.