Metabolism and Urinary Excretion of Chlormethiazole in Humans

R. G. Moore Department of Pharmacy, University of Sydney, Sydney, NSW, Australia, 2006

A. V. Robertson Department of Organic Chemistry, University of Sydney, Sydney, NSW, Australia, 2006

M. P. Smyth Department of Organic Chemistry, University of Sydney, Sydney, NSW, Australia, 2006

J. Thomas Department of Pharmacy, University of Sydney, Sydney, NSW, Australia, 2006

J. Vine Department of Organic Chemistry, University of Sydney, Sydney, NSW, Australia, 2006

Abstract

1. Chlormethiazole and five of its metabolites excreted in urine in man have been investigated by g.l.c.-mass spectrometry.

2. Four metabolites have been identified by comparison with authentic compounds as 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyl)-4-methylthiazole, 5-(2-hydroxyethyl)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid; 4-methyl-5-thiazoleacetaldehyde is proposed for the other metabolite.

3. The amounts of chlormethiazole and its identified metabolites excreted in urine have been quantitatively determined after a single oral dose in three healthy adults. Approximately 16% of the dose was excreted as chlormethiazole, 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyl)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Metabolism and Urinary Excretion of Chlormethiazole in Humans

Information for

Open access

Opportunities

Help and information

Metabolism and Urinary Excretion of Chlormethiazole in Humans

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature