Identification of Cyclobenzaprine-10, 11-Epoxide and other Metabolites after Incubation of Cyclobenzaprine with Rat Liver Microsomes

Abstract

1. The metabolism in vitro of cyclobenzaprine by rat liver microsomal preparations was investigated.

2. Four metabolic products, cyclobenzaprine N-oxide, 10,11-epoxycyclo-benzaprine N-oxide, desmethylcyclobenzaprine and cyclobenzaprine-10,11-epoxide were isolated and identified by comparing physical properties with those of authentic compounds.