Metabolism of 3-(Hydroxymethyl)-8-Methoxychromone in the rat: I. Absorption, Tissue Distribution and Excretion

Abstract

1. Two ¹⁴C-labelled preparations of 3-(hydroxymethyl)-8-methoxychromone were used to study the absorption, tissue distribution and excretion of isotope after oral administration to rats (20 mg/kg).

2. ¹⁴C, presumably from the labelled hydroxymethyl side-chain, was eliminated extensively as ¹⁴CC₂. This excretion was triphasic; kinetic constants were calculated for each phase.

3. The major excretion route was via the kidney although significant quantities of isotope were excreted with the faeces. Isotope did not accumulate in tissues.

2. London: Academic Press.

8. New York: J. Wiley & Sons, Inc.