Abstract
1. After administration of 2,4-diaminotoluene to rabbits, rats and guinea-pigs, phenolic metabolites are excreted, the major component being 5-hydroxy-2, 4-diaminotoluene in all species investigated. Acetylated aminophenols and glucuronide conjugates were also found.
2. Rabbits, which produced the largest amounts of free amino-phenols, also had the highest levels of methaemoglobin in vivo.