Studies on Metabolism of Trazodone IV. Intestinal Absorption in Rats and Rabbits

C. Yamato Department of Drug Metabolism, Section of Experimental Therapeutics Research, Tokyo, Japan; Research & Development Division, Eisai Co., Ltd., 4-chome, Koishi-kawa, Bunkyo-ku, Tokyo, Japan

T. Takahashi Department of Drug Metabolism, Section of Experimental Therapeutics Research, Tokyo, Japan; Research & Development Division, Eisai Co., Ltd., 4-chome, Koishi-kawa, Bunkyo-ku, Tokyo, Japan

T. Fujita Department of Drug Metabolism, Section of Experimental Therapeutics Research, Tokyo, Japan; Research & Development Division, Eisai Co., Ltd., 4-chome, Koishi-kawa, Bunkyo-ku, Tokyo, Japan

Abstract

1. The absorption rates are the same in rats and rabbits when [¹⁴C]trazodone HC1 is injected into the duodenum of animals with pyloric vein cannulation.

2. The absorption of trazodone from the duodenum of rats is rapid in comparison with that of imipramine.

3. The residual food content of the rabbit stomach after fasting delay the overall rate of trazodone absorption by markedly decreasing transit rate from the stomach to the small intestine.

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Studies on Metabolism of Trazodone IV. Intestinal Absorption in Rats and Rabbits

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