Identification of 3-Methyl-2-thiohydantoin, a Metabolite of Carbimazole, in Man

G. G. Skellern Drug Metabolism Research Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, G1 1XW, Scotland

B. I. Knight Drug Metabolism Research Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, G1 1XW, Scotland

F. M. Luman Drug Metabolism Research Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, G1 1XW, Scotland

J. B. Stenlake Drug Metabolism Research Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, G1 1XW, Scotland

D. G. McLarty Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, Scotland

M. J. Hooper Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow, G11 6NT, Scotland

Abstract

1. Classical and high-pressure liquid chromatographic separations were devised for the separation and isolation of the metabolite 3-methyl-2-thio-hydantoin from the urine of patients receiving carbimazole orally.

2. 3-Methyl-2-thiohydantoin was identified by comparing its absorption and mass spectral properties with authentic material.

3. 3-Methyl-2-thiohydantoin was also detected in the plasma of patients receiving methimazole intravenously.

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Identification of 3-Methyl-2-thiohydantoin, a Metabolite of Carbimazole, in Man

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Identification of 3-Methyl-2-thiohydantoin, a Metabolite of Carbimazole, in Man

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