Prodolic Acid: Analysis and Disposition Studies in Rats and Dogs

W. T. Robinson Ayerst Research Laboratories, Department of Biochemistry, P.O. Box 6115, Montreal, H3C 3J1, Canada

M. Kraml Ayerst Research Laboratories, Department of Biochemistry, P.O. Box 6115, Montreal, H3C 3J1, Canada

E. Greselin Ayerst Research Laboratories, Department of Biochemistry, P.O. Box 6115, Montreal, H3C 3J1, Canada

D. Dvornik Ayerst Research Laboratories, Department of Biochemistry, P.O. Box 6115, Montreal, H3C 3J1, Canada

Abstract

1. A specific fluorimetric method for the determination of prodolic acid in serum has been elaborated and has a limit of detection of 2 μg/mL

2. Common anti-inflammatory drugs do not interfere with the method.

3. In rats and dogs, prodolic acid is rapidly absorbed and has a short half-life of elimination.

4. The rate of elimination was marked by secondary rises in the blood level profile which were shown to be due to enterohepatic recirculation of prodolic acid.

5. Prodolic acid is highly bound to serum protein.

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Prodolic Acid: Analysis and Disposition Studies in Rats and Dogs

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