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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 1-2
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Research Article

Inhibition of 1,2-Dimethylhydrazine Metabolism by Disulfiram

E. S. Fiala Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
,
G. Bobotas Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
,
C. Kulakis Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
&
J. H. Weisburger Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
Pages 5-9 | Received 27 Feb 1976, Published online: 22 Sep 2008
 
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Abstract

1. The effects of disulfiram on the metabolism of 1,2-dimethylhydrazine were studied in CDF rats.

2. Treatment with disulfiram causes enhanced elimination of azomethane in the expired air, inhibition of CO2 production, and decreased levels of 1,2-dimethylhydrazine metabolites in the urine.

3. These results suggest that disulfiram inhibits the N-oxidation of azomethane to azoxymethane, thus preventing further metabolism to the ultimate carcinogenic species, and provide an explanation for the observations that disulfiram inhibits 1,2-dimethylhydrazine-induced neoplasia of the large intestine.

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