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Abstract
1. Non-pregnant and day-14 pregnant mice treated with a single dose of primidone (5 to 150 mg/kg) by gastric intubation were bled at 1 and 4 h after dosage, and the plasma analysed for primidone, phenobarbitone and phenyl-ethylmalondiamide (PEMA) by g.l.c.
2. Marked differences in the rate of metabolism were observed between the non-pregnant and day-14 pregnant mouse. Plasma levels of primidone and PEMA, but not phenobarbitone, were much lower in the day-14 pregnant mouse than in the non-pregnant animal.