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Abstract
The metabolism of N-ethyl-β-methoxy-β-(3'-trifluoromethyrphenyl)ethylamine (SKF 40652A, I) in vitro with 9000 g supernatants and washed microsomes of rabbit liver gave N-dealkylation, and N-oxidation of the parent secondary amine and the derived primary amine, anti and syn β-methoxy-β-(3'-trifluoromethylphenyl)acetaldoximes (V), and the β-methoxy-β-(3'-trifluoromethylphenyl)ethyl alcohol (VI). The identification and the physicochemical properties of these compounds are reported.