Metabolism of Arylacetic Acids: 2. The Fate of [¹⁴C]Hydratropic Acid and its Variation with Species

Abstract

1. (±)-[methyl-¹⁴C]-Hydratropic acid was administered to man, rhesus monkey, cat, rabbit and fruit bat.

2. All species excreted 60-100% oi administered ¹⁴C in the urine in 24 h, and unchanged hydratropic acid accounted for 0-17% of the dose.

3. In man, the urinary ¹⁴C consisted of a very small quantity (1%) of unchanged hydratropic acid with the remainder as hydratropylglucuronide.

4. Hydratropylglucuronide was the major urinary excretion product in the 4 animal species, while the glycine conjugate was present in the urine of cat and rat. Additionally, cats excreted the taurine conjugate of hydratropic acid.

5. Bile-duct cannulated rats excreted 20-30% of an injected dose of [¹⁴C] hydratropic acid in the bile in 3 h mainly as hydratropylglucuronide.