Bunolol Metabolism by Dogs: Urinary Excretion of 5-Hydroxytetralone

Abstract

1. Anion exchange and t.l.c. were used to collect the polar drug metabolites present in urine of dogs treated orally with [¹⁴C]bunolol.

2. A new metabolite, 5-hydroxytetralone, was isolated, purified, and identified by u.v., i.r. and mass spectroscopy.

3. 5-Hydroxytetralone represented 1.7% dose excreted in urine collected for 24 h after bunolol administration.

4. Properties of the metabolite are discussed in relation to the question of whether 5-hydroxytetralone was excreted as a conjugate.