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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 4
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Research Article

Metabolism of Butyl p-Nitrophenyl Ether in vitro with Rabbit Liver Preparations

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Pages 245-251 | Received 14 Mar 1977, Published online: 22 Sep 2008
 

Abstract

1. The metabolism of butyl p-nitrophenyl ether in vitro has been investigated with rabbit liver preparations.

2. Evidence for three metabolic pathways is presented. These involve initial microsomal hydroxylation at α, ω - 1 or the ω positions of the butyl chain.

3. (ω - 1)-Hydroxybutyl p-nitrophenyl ether was oxidized chiefly by the soluble fraction to the corresponding (ω - 1)-oxo derivative which spontaneously decomposed to give p-nitrophenol.

4. ω-Hydroxybutyl p-nitrophenyl ether identified as a metabolite was further oxidized by the soluble fraction to p-nitrophenoxybutyric acid.

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