The Fate of [¹⁰³Ru]Ruthenocene in Mice and Rats

Abstract

1. The metabolic fate, rate of excretion and organ distribution of [¹⁰³Ru]-ruthenocene, administered to mice intravenously, intraperitoneally and orally, were investigated.

2. Most of the ¹⁰³Ru was eliminated from the body in 24 h; the remainder was located mostly in liver, gastro-intestinal tract and fat and was slowly excreted.

3. The ¹⁰³Ru was excreted in the bile and urine as ruthenocene-O-glucuronide, as shown by enzymic hydrolysis and mass spectrum of the permethylated metabolite.