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Abstract
1. The metabolism of a number of xenobiotics has been investigated in isolated viable rat hepatocytes and kidney tubule fragments in suspension.
2. The level of Phase I metabolism was very low in the kidney cells although such cells possess appreciable Phase II metabolic capacity.
3. These findings are discussed in relation to the physiological role of cytochrome P-450 and the conjugating enzymes, and the value of intact cell systems in assessing inter-organ differences in xenobiotic metabolism.