Taurine Conjugation in Metabolism of 3-Phenoxybenzoic Acid and the Pyrethroid Insecticide Cypermethrin in Mouse

Abstract

1. A substantial proportion of the radioactivity of an oral dose (1-20 mg/kg) of 3-phenoxy[¹⁴C]benzoic acid and the pyrethroid insecticide trans- and cis-[aryl-¹⁴C]cypermethrin (an α-cyano-3-phenoxybenzyl ester) is eliminated rapidly in urine of mice.

2. The major urinary metabolite of these compounds in two strains of mice is N-(3-phenoxybenzoyl)taurine.

3. Neither 3-phenoxybenzoic acid nor cypermethrin gives a taurine conjugate in rats.

4. Benzoic acid gives no taurine conjugate in mice.